The cysteine-rich protein thimet oligopeptidase as a model of the structural requirements for S-glutathiolation and oxidative oligomerization.

The cysteine-rich protein thimet oligopeptidase as a model of the structural requirements for S-glutathiolation and oxidative oligomerization.

Thimet oligopeptidase (EP24.15) is a cysteine-rich metallopeptidase containing fifteen Cys residues and no intra-protein disulfide bonds. Previous work on this enzyme revealed that the oxidative oligomerization of EP24.15 is triggered by S-glutathiolation at physiological GSSG levels (10-50 µM) via...

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Bibliographic Details
Main Authors: Alberto Malvezzi, Patrícia M Higa, Antonia T-do Amaral, Gustavo M Silva, Fabio C Gozzo, Emer S Ferro, Leandro M Castro, Leandro de Rezende, Gisele Monteiro, Marilene Demasi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3382611?pdf=render

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http://europepmc.org/articles/PMC3382611?pdf=render

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