Transcriptional Activation of <i>Chac1</i> and Other Atf4-Target Genes Induced by Extracellular <span style="font-variant: small-caps">l</span>-Serine Depletion is negated with Glycine Consumption in Hepa1-6 Hepatocarcinoma Cells
Mouse embryonic fibroblasts lacking D-3-phosphoglycerate dehydrogenase (Phgdh), which catalyzes the first step of de novo synthesis of <span style="font-variant: small-caps;">l</span>-serine, are particularly sensitive to depletion of extracellular L-serine. In these cells, dep...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-10-01
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| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/12/10/3018 |