Population Pharmacokinetics and Initial Dose Optimization of Sirolimus Improving Drug Blood Level for Seizure Control in Pediatric Patients With Tuberous Sclerosis Complex

Population Pharmacokinetics and Initial Dose Optimization of Sirolimus Improving Drug Blood Level for Seizure Control in Pediatric Patients With Tuberous Sclerosis Complex

The purposes of this study were to explore the population pharmacokinetics and initial dose optimization of sirolimus improving drug blood level for seizure control in pediatric patients with tuberous sclerosis complex (TSC). Eighty pediatric patients diagnosed with TSC-related epilepsy were include...

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Bibliographic Details
Main Authors: Xiao Chen, Dongdong Wang, Lin Zhu, Jinmiao Lu, Yidie Huang, Guangfei Wang, Yiqing Zhu, Qiaofeng Ye, Yi Wang, Hong Xu, Zhiping Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
population pharmacokinetics
initial dose optimization
sirolimus
seizure control
tuberous sclerosis complex
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.647232/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.647232/full

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