Differential Regulation of Thyroid Hormone Metabolism Target Genes during Non-thyroidal Illness Syndrome Triggered by Fasting or Sepsis in Adult Mice

Differential Regulation of Thyroid Hormone Metabolism Target Genes during Non-thyroidal Illness Syndrome Triggered by Fasting or Sepsis in Adult Mice

Fasting and sepsis induce profound changes in thyroid hormone (TH) central and peripheral metabolism. These changes affect TH action and are called the non-thyroidal illness syndrome (NTIS). To date, it is still debated whether NTIS represents an adaptive response or a real hypothyroid state at the...

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Bibliographic Details
Main Authors: Klaus N. Fontes, Adriana Cabanelas, Flavia F. Bloise, Cherley Borba Vieira de Andrade, Luana L. Souza, Marianna Wilieman, Isis H. Trevenzoli, Lais C. Agra, Johnatas D. Silva, Christianne Bandeira-Melo, Pedro L. Silva, Patricia R. M. Rocco, Tania M. Ortiga-Carvalho
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Physiology
Subjects:
non-thyroidal illness syndrome
thyroid hormones
fasting
sepsis
CLP
thyroid hormone metabolism
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00828/full

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http://journal.frontiersin.org/article/10.3389/fphys.2017.00828/full

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