The ULK1-FBXW5-SEC23B nexus controls autophagy

The ULK1-FBXW5-SEC23B nexus controls autophagy

In response to nutrient deprivation, the cell mobilizes an extensive amount of membrane to form and grow the autophagosome, allowing the progression of autophagy. By providing membranes and stimulating LC3 lipidation, COPII (Coat Protein Complex II) promotes autophagosome biogenesis. Here, we show t...

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Bibliographic Details
Main Authors: Yeon-Tae Jeong, Daniele Simoneschi, Sarah Keegan, David Melville, Natalia S Adler, Anita Saraf, Laurence Florens, Michael P Washburn, Claudio N Cavasotto, David Fenyö, Ana Maria Cuervo, Mario Rossi, Michele Pagano
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-12-01
Series:eLife
Subjects:
human
cancer
cell
autophagy
ubiquitin
ULK1
Online Access:https://elifesciences.org/articles/42253

Internet

https://elifesciences.org/articles/42253

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