Mineralocorticoid receptor blockade with finerenone improves heart function and exercise capacity in ovariectomized mice

Mineralocorticoid receptor blockade with finerenone improves heart function and exercise capacity in ovariectomized mice

Abstract Aims In post‐menopausal women, incidence of heart failure with preserved ejection fraction is higher than in men. Hormonal replacement therapies did not demonstrate benefits. We tested whether the non‐steroidal mineralocorticoid receptor antagonist finerenone limits the progression of heart...

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Bibliographic Details
Main Authors: Marie Pieronne‐Deperrois, Alexandre Guéret, Zoubir Djerada, Clément Crochemore, Najah Harouki, Jean‐Paul Henry, Anaïs Dumesnil, Marine Larchevêque, Jean‐Claude doRego, Jean‐Luc doRego, Lionel Nicol, Vincent Richard, Frédéric Jaisser, Peter Kolkhof, Paul Mulder, Christelle Monteil, Antoine Ouvrard‐Pascaud
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:ESC Heart Failure
Subjects:
Mineralocorticoid receptor
Aldosterone
Diastolic dysfunction
Exercise
Ovariectomy
Menopause
Online Access:https://doi.org/10.1002/ehf2.13219

Internet

https://doi.org/10.1002/ehf2.13219

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