Combination of the natural product capsaicin and docetaxel synergistically kills human prostate cancer cells through the metabolic regulator AMP-activated kinase

Combination of the natural product capsaicin and docetaxel synergistically kills human prostate cancer cells through the metabolic regulator AMP-activated kinase

Abstract Background Current chemotherapy for castration-resistant prostate cancer is established on taxane-based compounds like docetaxel. However, eventually, the development of toxic side effects and resistance limits the therapeutic benefit being the major concern in the treatment of prostate can...

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Bibliographic Details
Main Authors: Belén G. Sánchez, Alicia Bort, Pedro A. Mateos-Gómez, Nieves Rodríguez-Henche, Inés Díaz-Laviada
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Cancer Cell International
Subjects:
Docetaxel
Capsaicin
AMPK
PC3 cells
LNCaP cells
Prostate cancer
Online Access:http://link.springer.com/article/10.1186/s12935-019-0769-2

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http://link.springer.com/article/10.1186/s12935-019-0769-2

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