miR-150-Mediated Foxo1 Regulation Programs CD8+ T Cell Differentiation

miR-150-Mediated Foxo1 Regulation Programs CD8+ T Cell Differentiation

MicroRNA (miR)-150 is a developmental regulator of several immune-cell types, but its role in CD8+ T cells is largely unexplored. Here, we show that miR-150 regulates the generation of memory CD8+ T cells. After acute virus infection, miR-150 knockout (KO) mice exhibited an accelerated differentiati...

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Bibliographic Details
Main Authors: Young Ho Ban, Se-Chan Oh, Sang-Hwan Seo, Seok-Min Kim, In-Pyo Choi, Philip D. Greenberg, Jun Chang, Tae-Don Kim, Sang-Jun Ha
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
miR-150
Foxo1
CD8
memory
differentiation
acute
infection
primary immune response
recall
LCMV
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717311907

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http://www.sciencedirect.com/science/article/pii/S2211124717311907

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