Encapsulated GDNF-producing C2C12 cells for Parkinson's disease: a pre-clinical study in chronic MPTP-treated baboons

Encapsulated GDNF-producing C2C12 cells for Parkinson's disease: a pre-clinical study in chronic MPTP-treated baboons

Glial cell line-derived neurotrophic factor (GDNF), a potent neurotrophic factor with restorative effects in a variety of rodent and primate models of Parkinson's disease (PD), could be of therapeutic value to PD. In this study, we show that intraventricular chronic infusion of low doses of GDN...

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Bibliographic Details
Main Authors: Haruhiko Kishima, Thomas Poyot, Jocelyne Bloch, Julien Dauguet, Françoise Condé, Frédéric Dollé, Françoise Hinnen, William Pralong, Stéphane Palfi, Nicole Déglon, Patrick Aebischer, Philippe Hantraye
Format: Article
Language:English
Published: Elsevier 2004-07-01
Series:Neurobiology of Disease
Subjects:
Glial cell line-derived neurotrophic factor
Parkinson disease
Neurotrophic factor
Macroencapsulation
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Baboon
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104000737

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http://www.sciencedirect.com/science/article/pii/S0969996104000737

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