Is the Efficiency of RNA Silencing Evolutionarily Regulated?

Is the Efficiency of RNA Silencing Evolutionarily Regulated?

Small interfering RNAs (siRNAs) and microRNAs (miRNAs) regulate gene expression in a sequence-specific manner. Genes with partial complementarity to siRNA/miRNA sequences in their 3′-untranslated regions (UTRs) are suppressed by a mechanism referred to as the siRNA off-target effect or miRNA-mediate...

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Bibliographic Details
Main Author: Kumiko Ui-Tei
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:International Journal of Molecular Sciences
Subjects:
RNA silencing
siRNA
miRNA
silencing efficiency
base-pairing stability
thermodynamic stability
Online Access:http://www.mdpi.com/1422-0067/17/5/719

Internet

http://www.mdpi.com/1422-0067/17/5/719

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