miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence.

miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence.

Hepatitis C virus (HCV) requires the liver specific micro-RNA (miRNA), miR-122, to replicate. This was considered unique among RNA viruses until recent discoveries of HCV-related hepaciviruses prompting the question of a more general miR-122 dependence. Among hepaciviruses, the closest known HCV rel...

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Bibliographic Details
Main Authors: Yingpu Yu, Troels K H Scheel, Joseph M Luna, Hachung Chung, Eiko Nishiuchi, Margaret A Scull, Natalia Echeverría, Inna Ricardo-Lax, Amit Kapoor, W Ian Lipkin, Thomas J Divers, Douglas F Antczak, Bud C Tennant, Charles M Rice
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-10-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1006694

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https://doi.org/10.1371/journal.ppat.1006694

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