DTL promotes cancer progression by PDCD4 ubiquitin-dependent degradation
Abstract Background Ubiquitin E3 ligase CUL4A plays important oncogenic roles in the development of cancers. DTL, one of the CUL4-DDB1 associated factors (DCAFs), may involve in the process of cancer development. Programmed cell death 4 (PDCD4) is a tumor suppressor gene involved in cell apoptosis,...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-08-01
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Series: | Journal of Experimental & Clinical Cancer Research |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13046-019-1358-x |