DTL promotes cancer progression by PDCD4 ubiquitin-dependent degradation

DTL promotes cancer progression by PDCD4 ubiquitin-dependent degradation

Abstract Background Ubiquitin E3 ligase CUL4A plays important oncogenic roles in the development of cancers. DTL, one of the CUL4-DDB1 associated factors (DCAFs), may involve in the process of cancer development. Programmed cell death 4 (PDCD4) is a tumor suppressor gene involved in cell apoptosis,...

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Bibliographic Details
Main Authors: Haoran Cui, Qin Wang, Zhenchuan Lei, Maoxiao Feng, Zhongxi Zhao, Yunshan Wang, Guangwei Wei
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
DTL
CUL4A
PDCD4
Cancer development
Online Access:http://link.springer.com/article/10.1186/s13046-019-1358-x

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http://link.springer.com/article/10.1186/s13046-019-1358-x

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