Neuroinflammation in Ischemic Stroke: Inhibition of cAMP-Specific Phosphodiesterases (PDEs) to the Rescue

Neuroinflammation in Ischemic Stroke: Inhibition of cAMP-Specific Phosphodiesterases (PDEs) to the Rescue

Ischemic stroke is caused by a thromboembolic occlusion of a major cerebral artery, with the impaired blood flow triggering neuroinflammation and subsequent neuronal damage. Both the innate immune system (e.g., neutrophils, monocytes/macrophages) in the acute ischemic stroke phase and the adaptive i...

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Bibliographic Details
Main Authors: Laura Ponsaerts, Lotte Alders, Melissa Schepers, Rúbia Maria Weffort de Oliveira, Jos Prickaerts, Tim Vanmierlo, Annelies Bronckaers
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biomedicines
Subjects:
ischemic stroke
neuroinflammation
neuroplasticity
PDE4
PDE7
PDE8
Online Access:https://www.mdpi.com/2227-9059/9/7/703

Internet

https://www.mdpi.com/2227-9059/9/7/703

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