The critical roles of activated stellate cells-mediated paracrine signaling, metabolism and onco-immunology in pancreatic ductal adenocarcinoma

The critical roles of activated stellate cells-mediated paracrine signaling, metabolism and onco-immunology in pancreatic ductal adenocarcinoma

Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant diseases worldwide. It is refractory to conventional treatments, and consequently has a documented 5-year survival rate as low as 7%. Increasing evidence indicates that activated pancreatic stellate cells (PSCs), on...

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Bibliographic Details
Main Authors: Yaojie Fu, Shanshan Liu, Shan Zeng, Hong Shen
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Molecular Cancer
Subjects:
Pancreatic stellate cells
PDAC
Metabolic reprogramming
Immune evasion
Drug resistance
Online Access:http://link.springer.com/article/10.1186/s12943-018-0815-z

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http://link.springer.com/article/10.1186/s12943-018-0815-z

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