Mapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell Circuits

Mapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell Circuits

cAMP signaling has powerful, negative effects on cognitive functions of the primate dorsolateral prefrontal cortex (dlPFC), opening potassium channels to reduce firing and impair working memory, and increasing tau phosphorylation in aging neurons. This contrasts with cAMP actions in classic circuits...

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Bibliographic Details
Main Authors: Dibyadeep Datta, John F. Enwright, Dominique Arion, Constantinos D. Paspalas, Yury M. Morozov, David A. Lewis, Amy F. T. Arnsten
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Neuroanatomy
Subjects:
prefrontal cortex
PDE4D
cAMP
pyramidal cell
calcium
microdomains
Online Access:https://www.frontiersin.org/articles/10.3389/fnana.2020.578483/full

Internet

https://www.frontiersin.org/articles/10.3389/fnana.2020.578483/full

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