DNA Topoisomerase I differentially modulates R-loops across the human genome

DNA Topoisomerase I differentially modulates R-loops across the human genome

Abstract Background Co-transcriptional R-loops are abundant non-B DNA structures in mammalian genomes. DNA Topoisomerase I (Top1) is often thought to regulate R-loop formation owing to its ability to resolve both positive and negative supercoils. How Top1 regulates R-loop structures at a global leve...

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Bibliographic Details
Main Authors: Stefano G. Manzo, Stella R. Hartono, Lionel A. Sanz, Jessica Marinello, Sara De Biasi, Andrea Cossarizza, Giovanni Capranico, Frederic Chedin
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Genome Biology
Online Access:http://link.springer.com/article/10.1186/s13059-018-1478-1

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http://link.springer.com/article/10.1186/s13059-018-1478-1

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