Pathway analysis identifies altered mitochondrial metabolism, neurotransmission, structural pathways and complement cascade in retina/RPE/ choroid in chick model of form-deprivation myopia

Pathway analysis identifies altered mitochondrial metabolism, neurotransmission, structural pathways and complement cascade in retina/RPE/ choroid in chick model of form-deprivation myopia

Purpose RNA sequencing analysis has demonstrated bidirectional changes in metabolism, structural and immune pathways during early induction of defocus induced myopia. Thus, the aim of this study was to investigate whether similar gene pathways are also related to the more excessive axial growth, ult...

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Bibliographic Details
Main Authors: Loretta Giummarra, Sheila G. Crewther, Nina Riddell, Melanie J. Murphy, David P. Crewther
Format: Article
Language:English
Published: PeerJ Inc. 2018-06-01
Series:PeerJ
Subjects:
Gene set enrichment analysis
Myopia
Mitochondrial energy metabolism
Neurotransmission
Bile acid metabolism
Online Access:https://peerj.com/articles/5048.pdf

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https://peerj.com/articles/5048.pdf

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