Simultaneous Subcutaneous and Intranasal Administration of a CAF01-Adjuvanted Chlamydia Vaccine Elicits Elevated IgA and Protective Th1/Th17 Responses in the Genital Tract

Simultaneous Subcutaneous and Intranasal Administration of a CAF01-Adjuvanted Chlamydia Vaccine Elicits Elevated IgA and Protective Th1/Th17 Responses in the Genital Tract

The selection of any specific immunization route is critical when defining future vaccine strategies against a genital infection like Chlamydia trachomatis (C.t.). An optimal Chlamydia vaccine needs to elicit mucosal immunity comprising both neutralizing IgA/IgG antibodies and strong Th1/Th17 respon...

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Bibliographic Details
Main Authors: Jeanette Erbo Wern, Maria Rathmann Sorensen, Anja Weinreich Olsen, Peter Andersen, Frank Follmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Immunology
Subjects:
mucosal immunization
IgA
Chlamydia
vaccine
heterologous immunization routes
genital infection
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00569/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00569/full

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