Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma

Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma

<p>Abstract</p> <p>Background</p> <p>We have previously reported that the sigma-2 receptor is highly expressed in pancreas cancer. Furthermore, we have demonstrated that sigma-2 receptor specific ligands induce apoptosis in a dose-dependent fashion. Here, we examined wh...

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Bibliographic Details
Main Authors: Chang Katherine, Vangveravong Suwanna, Goedegebuure Peter S, Simon Peter O, McDunn Jonathan E, Kashiwagi Hiroyuki, Hotchkiss Richard S, Mach Robert H, Hawkins William G
Format: Article
Language:English
Published: BMC 2009-03-01
Series:Journal of Translational Medicine
Online Access:http://www.translational-medicine.com/content/7/1/24

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http://www.translational-medicine.com/content/7/1/24

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