Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in mice.

Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in mice.

Anti-nicotine vaccines may aid smoking cessation via the induction of anti-nicotine antibodies (Ab) which reduce nicotine entering the brain, and hence the associated reward. Ab function depends on both the quantity (titer) and the quality (affinity) of the Ab. Anti-nicotine vaccines tested previous...

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Bibliographic Details
Main Authors: David C Pryde, Lyn H Jones, David P Gervais, David R Stead, David C Blakemore, Matthew D Selby, Alan D Brown, Jotham W Coe, Matthew Badland, David M Beal, Rebecca Glen, Yvonne Wharton, Gavin J Miller, Phil White, Ningli Zhang, Michelle Benoit, Karen Robertson, James R Merson, Heather L Davis, Michael J McCluskie
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3788104?pdf=render

Internet

http://europepmc.org/articles/PMC3788104?pdf=render

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