Synthesis and antimicrobial evaluation of two peptide LyeTx I derivatives modified with the chelating agent HYNIC for radiolabeling with technetium-99m

Synthesis and antimicrobial evaluation of two peptide LyeTx I derivatives modified with the chelating agent HYNIC for radiolabeling with technetium-99m

Abstract Background Current diagnostic methods and imaging techniques are not able to differentiate septic and aseptic inflammation. Thus, reliable methods are sought to provide this distinction and scintigraphic imaging is an interesting option, since it is based on physiological changes. In this...

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Bibliographic Details
Main Authors: Leonardo Lima Fuscaldi, Daniel Moreira dos Santos, Natália Gabriela Silva Pinheiro, Raquel Silva Araújo, André Luís Branco de Barros, Jarbas Magalhães Resende, Simone Odília Antunes Fernandes, Maria Elena de Lima, Valbert Nascimento Cardoso
Format: Article
Language:English
Published: SciELO 2016-05-01
Series:Journal of Venomous Animals and Toxins including Tropical Diseases
Subjects:
Septic and aseptic inflammation
Differential diagnosis
Antimicrobial peptides LyeTx I derivatives
MALDI-ToF-MS RP-HPLC
Technetium-99m
HYNIC EDDA Tricine
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100312&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100312&lng=en&tlng=en

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