Preventing Overflow Metabolism in Crabtree-Positive Microorganisms through On-Line Monitoring and Control of Fed-Batch Fermentations

Preventing Overflow Metabolism in Crabtree-Positive Microorganisms through On-Line Monitoring and Control of Fed-Batch Fermentations

At specific growth rates above a particular critical value, Crabtree-positive microorganisms exceed their respiratory capacity and enter diauxic growth metabolism. Excess substrate is converted reductively to an overflow metabolite, resulting in decreased biomass yield and productivity. To prevent t...

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Bibliographic Details
Main Authors: Loïc Habegger, Kelly Rodrigues Crespo, Michal Dabros
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Fermentation
Subjects:
bioprocess monitoring and control
Crabtree effect
overflow metabolism
specific growth rate control
BioPAT
Online Access:http://www.mdpi.com/2311-5637/4/3/79

Internet

http://www.mdpi.com/2311-5637/4/3/79

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