Preventing Overflow Metabolism in Crabtree-Positive Microorganisms through On-Line Monitoring and Control of Fed-Batch Fermentations
At specific growth rates above a particular critical value, Crabtree-positive microorganisms exceed their respiratory capacity and enter diauxic growth metabolism. Excess substrate is converted reductively to an overflow metabolite, resulting in decreased biomass yield and productivity. To prevent t...
Main Authors: | Loïc Habegger, Kelly Rodrigues Crespo, Michal Dabros |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2018-09-01
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Series: | Fermentation |
Subjects: | |
Online Access: | http://www.mdpi.com/2311-5637/4/3/79 |
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