In utero alcohol exposure exacerbates endothelial protease activity from pial microvessels and impairs GABA interneuron positioning

In utero alcohol exposure exacerbates endothelial protease activity from pial microvessels and impairs GABA interneuron positioning

In utero alcohol exposure can induce severe neurodevelopmental disabilities leading to long-term behavioral deficits. Because alcohol induces brain defects, many studies have focused on nervous cells. However, recent reports have shown that alcohol markedly affects cortical angiogenesis in both anim...

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Bibliographic Details
Main Authors: Cécile Léger, Nicolas Dupré, Annie Laquerrière, Maryline Lecointre, Marion Dumanoir, François Janin, Michelle Hauchecorne, Maëlle Fabre, Sylvie Jégou, Thierry Frébourg, Carine Cleren, Philippe Leroux, Pascale Marcorelles, Carole Brasse-Lagnel, Stéphane Marret, Florent Marguet, Bruno J. Gonzalez
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Neurobiology of Disease
Subjects:
Fetal alcohol spectrum disorder
Neurovascular
Endothelial cells
GABA interneurons
Matrix metalloproteinase-9 (MMP-9)
Tissue plasminogen activator (tPA)
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120303491

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http://www.sciencedirect.com/science/article/pii/S0969996120303491

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