Smooth Muscle Phenotype in Idiopathic Pulmonary Hypertension: Hyper-Proliferative but not Cancerous

Smooth Muscle Phenotype in Idiopathic Pulmonary Hypertension: Hyper-Proliferative but not Cancerous

Idiopathic pulmonary arterial hypertension (IPAH) is a complex disease associated with vascular remodeling and a proliferative disorder in pulmonary artery smooth muscle cells (PASMCs) that has been variably described as having neoplastic features. To decode the phenotype of PASMCs in IPAH, PASMCs f...

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Bibliographic Details
Main Authors: Frédéric Perros, Pierre Sentenac, David Boulate, Grégoire Manaud, Tom Kotsimbos, Florence Lecerf, Lilia Lamrani, Elie Fadel, Olaf Mercier, Arturo Londono-Vallejo, Marc Humbert, Saadia Eddahibi
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
idiopathic pulmonary artery hypertension
pulmonary artery smooth muscle cells
proliferation
energetic metabolism
DNA damage.
Online Access:https://www.mdpi.com/1422-0067/20/14/3575

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https://www.mdpi.com/1422-0067/20/14/3575

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