Development of a Rapid Throughput Assay for Identification of hNav1.7 Antagonist Using Unique Efficacious Sodium Channel Agonist, Antillatoxin

Development of a Rapid Throughput Assay for Identification of hNav1.7 Antagonist Using Unique Efficacious Sodium Channel Agonist, Antillatoxin

Voltage-gated sodium channels (VGSCs) are responsible for the generation of the action potential. Among nine classified VGSC subtypes (Nav1.1–Nav1.9), Nav1.7 is primarily expressed in the sensory neurons, contributing to the nociception transmission. Therefore Nav1.7 becomes a promising target for a...

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Bibliographic Details
Main Authors: Fang Zhao, Xichun Li, Liang Jin, Fan Zhang, Masayuki Inoue, Boyang Yu, Zhengyu Cao
Format: Article
Language:English
Published: MDPI AG 2016-02-01
Series:Marine Drugs
Subjects:
antillatoxin
FMPblue
membrane potential
hNav1.7
rapid throughput
Online Access:http://www.mdpi.com/1660-3397/14/2/36

Internet

http://www.mdpi.com/1660-3397/14/2/36

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