A modified RMCE-compatible Rosa26 locus for the expression of transgenes from exogenous promoters.

A modified RMCE-compatible Rosa26 locus for the expression of transgenes from exogenous promoters.

Generation of gain-of-function transgenic mice by targeting the Rosa26 locus has been established as an alternative to classical transgenic mice produced by pronuclear microinjection. However, targeting transgenes to the endogenous Rosa26 promoter results in moderate ubiquitous expression and is not...

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Main Authors: Jan S Tchorz, Thomas Suply, Iwona Ksiazek, Claudio Giachino, Dimitri Cloëtta, Claus-Peter Danzer, Thierry Doll, Andrea Isken, Marianne Lemaistre, Verdon Taylor, Bernhard Bettler, Bernd Kinzel, Matthias Mueller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3258265?pdf=render

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http://europepmc.org/articles/PMC3258265?pdf=render

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