BML-265 and Tyrphostin AG1478 Disperse the Golgi Apparatus and Abolish Protein Transport in Human Cells

BML-265 and Tyrphostin AG1478 Disperse the Golgi Apparatus and Abolish Protein Transport in Human Cells

The steady-state localization of Golgi-resident glycosylation enzymes in the Golgi apparatus depends on a balance between anterograde and retrograde transport. Using the Retention Using Selective Hooks (RUSH) assay and high-content screening, we identified small molecules that perturb the localizati...

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Bibliographic Details
Main Authors: Gaelle Boncompain, Nelly Gareil, Sarah Tessier, Aurianne Lescure, Thouis R. Jones, Oliver Kepp, Guido Kroemer, Elaine Del Nery, Franck Perez
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
golgi
membrane trafficking
high-content screening
EGFR kinase inhibitor
GBF1
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00232/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2019.00232/full

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