Effect of Roflumilast in airways disorders via dual inhibition of phosphodiesterase and Ca2+-channel

Effect of Roflumilast in airways disorders via dual inhibition of phosphodiesterase and Ca2+-channel

The bronchodilator effects of Roflumilast “a selective phosphodiesterase type-4 (PDE4)” inhibitor studied in this experimental protocol. The spiral strips of isolated guinea-pig tracheal chains mounted in organ bath and maintained in Krebs solution ventilated with carbogen at 32 °C and in Ca++ restr...

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Bibliographic Details
Main Authors: Faisal Imam, Najeeb Ur Rehman, Mohd Nazam Ansari, Wajhul Qamar, Muhammad Afzal, Khalid Saad Alharbi
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Saudi Pharmaceutical Journal
Subjects:
Roflumilast
Bronchodilatation
Papaverine
Phosphodiesterase inhibitor
Ca++ channel blocker
Online Access:http://www.sciencedirect.com/science/article/pii/S131901642030089X

Internet

http://www.sciencedirect.com/science/article/pii/S131901642030089X

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