Targeting a cysteine protease from a pathobiont alleviates experimental arthritis

Targeting a cysteine protease from a pathobiont alleviates experimental arthritis

Abstract Background Several lines of evidence suggest that the pathobiont Porphyromonas gingivalis is involved in the development and/or progression of auto-inflammatory diseases. This bacterium produces cysteine proteases, such as gingipain RgpA, endowed with the potential to induce significant bon...

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Bibliographic Details
Main Authors: Hsin-Yi Peng, Shih-Yao Chen, Shih-Hong Siao, Jinghua Tsai Chang, Ting-Yin Xue, Yi-Hsuan Lee, Ming-Shiou Jan, Gregory J. Tsay, Moncef Zouali
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
Periodontitis
Porphyromonas gingivalis
Gingipain
Collagen-induced arthritis
Online Access:http://link.springer.com/article/10.1186/s13075-020-02205-z

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http://link.springer.com/article/10.1186/s13075-020-02205-z

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