A High-Throughput Screening Identifies MICU1 Targeting Compounds

A High-Throughput Screening Identifies MICU1 Targeting Compounds

Summary: Mitochondrial Ca2+ uptake depends on the mitochondrial calcium uniporter (MCU) complex, a highly selective channel of the inner mitochondrial membrane (IMM). Here, we screen a library of 44,000 non-proprietary compounds for their ability to modulate mitochondrial Ca2+ uptake. Two of them, n...

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Bibliographic Details
Main Authors: Giulia Di Marco, Francesca Vallese, Benjamin Jourde, Christian Bergsdorf, Mattia Sturlese, Agnese De Mario, Valerie Techer-Etienne, Dorothea Haasen, Berndt Oberhauser, Simone Schleeger, Giulia Minetti, Stefano Moro, Rosario Rizzuto, Diego De Stefani, Mara Fornaro, Cristina Mammucari
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720301157

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http://www.sciencedirect.com/science/article/pii/S2211124720301157

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