Live cell imaging and proteomic profiling of endogenous NEAT1 lncRNA by CRISPR/Cas9-mediated knock-in
Abstract In mammalian cells, long noncoding RNAs (lncRNAs) form complexes with proteins to execute various biological functions such as gene transcription, RNA processing and other signaling activities. However, methods to track endogenous lncRNA dynamics in live cells and screen for lncRNA interact...
Main Authors: | Bohong Chen, Shengcheng Deng, Tianyu Ge, Miaoman Ye, Jianping Yu, Song Lin, Wenbin Ma, Zhou Songyang |
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Format: | Article |
Language: | English |
Published: |
SpringerOpen
2020-05-01
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Series: | Protein & Cell |
Subjects: | |
Online Access: | https://doi.org/10.1007/s13238-020-00706-w |
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