Multiple copies of the oxytetracycline gene cluster in selected Streptomyces rimosus strains can provide significantly increased titers

Multiple copies of the oxytetracycline gene cluster in selected Streptomyces rimosus strains can provide significantly increased titers

Abstract Background Natural products are a valuable source of biologically active compounds that have applications in medicine and agriculture. One disadvantage with natural products is the slow, time-consuming strain improvement regimes that are necessary to ensure sufficient quantities of target c...

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Bibliographic Details
Main Authors: Špela Pikl, Andrés Felipe Carrillo Rincón, Lucija Slemc, Dušan Goranovič, Martina Avbelj, Krešimir Gjuračić, Hilda Sucipto, Katja Stare, Špela Baebler, Martin Šala, Meijin Guo, Andriy Luzhetskyy, Hrvoje Petković, Vasilka Magdevska
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Microbial Cell Factories
Subjects:
Streptomyces rimosus
Oxytetracycline
ΦC31
Biosynthesis
Biosynthetic gene cluster
Online Access:https://doi.org/10.1186/s12934-021-01522-5

Internet

https://doi.org/10.1186/s12934-021-01522-5

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