TAPBPR mediates peptide dissociation from MHC class I using a leucine lever

TAPBPR mediates peptide dissociation from MHC class I using a leucine lever

Tapasin and TAPBPR are known to perform peptide editing on major histocompatibility complex class I (MHC I) molecules; however, the precise molecular mechanism(s) involved in this process remain largely enigmatic. Here, using immunopeptidomics in combination with novel cell-based assays that assess...

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Bibliographic Details
Main Authors: F Tudor Ilca, Andreas Neerincx, Clemens Hermann, Ana Marcu, Stefan Stevanović, Janet E Deane, Louise H Boyle
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-11-01
Series:eLife
Subjects:
antigen processing
antigen presentation
major histocompatibility complex
TAPBPR/TAPBPL
Online Access:https://elifesciences.org/articles/40126

Internet

https://elifesciences.org/articles/40126

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