Selective reduction of striatal mature BDNF without induction of proBDNF in the zQ175 mouse model of Huntington's disease

Selective reduction of striatal mature BDNF without induction of proBDNF in the zQ175 mouse model of Huntington's disease

Huntington's disease (HD) is a neurodegenerative disorder characterized by massive loss of medium spiny neurons in the striatum. However, the mechanisms by which mutant huntingtin leads to this selective neuronal death remain incompletely understood. Brain-derived neurotrophic factor (BDNF) has...

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Bibliographic Details
Main Authors: Qian Ma, Jianmin Yang, Thomas Li, Teresa A. Milner, Barbara L. Hempstead
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
zQ175 mice
Cortex
Striatum
ProBDNF
Mature BDNF
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115300292

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http://www.sciencedirect.com/science/article/pii/S0969996115300292

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