Optical Spike Detection and Connectivity Analysis With a Far-Red Voltage-Sensitive Fluorophore Reveals Changes to Network Connectivity in Development and Disease

Optical Spike Detection and Connectivity Analysis With a Far-Red Voltage-Sensitive Fluorophore Reveals Changes to Network Connectivity in Development and Disease

The ability to optically record dynamics of neuronal membrane potential promises to revolutionize our understanding of neurobiology. In this study, we show that the far-red voltage sensitive fluorophore, Berkeley Red Sensor of Transmembrane potential-1, or BeRST 1, can be used to monitor neuronal me...

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Bibliographic Details
Main Authors: Alison S. Walker, Benjamin K. Raliski, Kaveh Karbasi, Patrick Zhang, Kate Sanders, Evan W. Miller
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Neuroscience
Subjects:
action potential
connectivity
neuronal network
spike timing correlation
fluorescent indicators
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.643859/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.643859/full

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