Intratumoral Decorin Gene Delivery by AAV Vector Inhibits Brain Glioblastomas and Prolongs Survival of Animals by Inducing Cell Differentiation

Intratumoral Decorin Gene Delivery by AAV Vector Inhibits Brain Glioblastomas and Prolongs Survival of Animals by Inducing Cell Differentiation

Glioblastoma multiforme (GBM) is the most malignant cancer in the central nervous system with poor clinical prognosis. In this study, we investigated the therapeutic effect of an anti-cancer protein, decorin, by delivering it into a xenograft U87MG glioma tumor in the brain of nude mice through an a...

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Bibliographic Details
Main Authors: Hsin-I Ma, Dueng-Yuan Hueng, Hao-Ai Shui, Jun-Ming Han, Chi-Hsien Wang, Ying-Hsiu Lai, Shi-Yuan Cheng, Xiao Xiao, Ming-Teh Chen, Yi-Ping Yang
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:International Journal of Molecular Sciences
Subjects:
dsAAV
decorin
glioblastoma multiforme
proteomics
2-D electrophoresis
Online Access:http://www.mdpi.com/1422-0067/15/3/4393

Internet

http://www.mdpi.com/1422-0067/15/3/4393

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