Role of Free Radicals and Biotransformation in Trichloronitrobenzene-Induced Nephrotoxicity In Vitro

Role of Free Radicals and Biotransformation in Trichloronitrobenzene-Induced Nephrotoxicity In Vitro

This study determined the comparative nephrotoxic potential of four trichloronitrobenzenes (TCNBs) (2,3,4-; 2,4,5-; 2,4,6-; and 3,4,5-TCNB) and explored the effects of antioxidants and biotransformation inhibitors on TCNB-induced cytotoxicity in isolated renal cortical cells (IRCC) from male Fischer...

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Bibliographic Details
Main Authors: Gary O. Rankin, Connor Tyree, Deborah Pope, Jordan Tate, Christopher Racine, Dianne K. Anestis, Kathleen C. Brown, Mason Dial, Monica A. Valentovic
Format: Article
Language:English
Published: MDPI AG 2017-05-01
Series:International Journal of Molecular Sciences
Subjects:
trichloronitrobenzenes
nephrotoxicity
in vitro
antioxidants
biotransformation
Online Access:http://www.mdpi.com/1422-0067/18/6/1165

Internet

http://www.mdpi.com/1422-0067/18/6/1165

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