High-throughput, single-particle tracking reveals nested membrane domains that dictate KRasG12D diffusion and trafficking

High-throughput, single-particle tracking reveals nested membrane domains that dictate KRasG12D diffusion and trafficking

Membrane nanodomains have been implicated in Ras signaling, but what these domains are and how they interact with Ras remain obscure. Here, using single particle tracking with photoactivated localization microscopy (spt-PALM) and detailed trajectory analysis, we show that distinct membrane domains d...

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Bibliographic Details
Main Authors: Yerim Lee, Carey Phelps, Tao Huang, Barmak Mostofian, Lei Wu, Ying Zhang, Kai Tao, Young Hwan Chang, Philip JS Stork, Joe W Gray, Daniel M Zuckerman, Xiaolin Nan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-11-01
Series:eLife
Subjects:
Ras
membrane nanodomain
single-particle tracking
diffusion
endocytosis
non-equilibrium steady state
Online Access:https://elifesciences.org/articles/46393

Internet

https://elifesciences.org/articles/46393

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