Biochemical and genetic analysis of butyrylcholinesterase (BChE) in a family, due to prolonged neuromuscular blockade after the use of succinylcholine

Biochemical and genetic analysis of butyrylcholinesterase (BChE) in a family, due to prolonged neuromuscular blockade after the use of succinylcholine

Butyrylcholinesterase (BChE) is a plasma enzyme that catalyzes the hydrolysis of choline esters, including the muscle-relaxant succinylcholine and mivacurium. Patients who present sustained neuromuscular blockade after using succinylcholine usually carry BChE variants with reduced enzyme activity or...

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Bibliographic Details
Main Authors: Daniel Fantozzi Garcia, Ticiano G. Oliveira, Greice A. Molfetta, Luiz V. Garcia, Cristiane A. Ferreira, Adriana A. Marques, Wilson Araujo Silva Jr.
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2011-01-01
Series:Genetics and Molecular Biology
Subjects:
hereditary hypocholinesterasemia
butyrylcholinesterase
succinylcholine BCHE gene
DNA polymorphism
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000100008

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000100008

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