Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease.

Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease.

BACKGROUND: Chagas disease induced by Trypanosoma cruzi (T. cruzi) infection is a major cause of mortality and morbidity affecting the cardiovascular system for which presently available therapies are largely inadequate. Transforming Growth Factor beta (TGFß) has been involved in several regulatory...

Full description

Bibliographic Details
Main Authors: Fabiane L de Oliveira, Tania C Araújo-Jorge, Elen M de Souza, Gabriel M de Oliveira, Wim M Degrave, Jean-Jacques Feige, Sabine Bailly, Mariana C Waghabi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3373641?pdf=render

Internet

http://europepmc.org/articles/PMC3373641?pdf=render

Similar Items