Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells.

Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells.

Canonical Wnt/β-catenin signaling has been suggested to promote self-renewal of pluripotent mouse and human embryonic stem cells. Here, we show that SB-216763, a glycogen synthase kinase-3 (GSK3) inhibitor, can maintain mouse embryonic stem cells (mESCs) in a pluripotent state in the absence of exog...

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Bibliographic Details
Main Authors: Leslie A Kirby, Jason T Schott, Brenda L Noble, Daniel C Mendez, Paul S Caseley, Sarah C Peterson, Tyler J Routledge, Nilay V Patel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3383737?pdf=render

Internet

http://europepmc.org/articles/PMC3383737?pdf=render

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