Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures

Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures

Toll-like receptor 4 (TLR4) activation in neuron and astrocytes by High Mobility Group Box 1 (HMGB1) protein is a key mechanism of seizure generation. HMGB1 also activates the Receptor for Advanced Glycation Endproducts (RAGE), but it was unknown whether RAGE activation contributes to seizures or to...

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Bibliographic Details
Main Authors: Valentina Iori, Mattia Maroso, Massimo Rizzi, Anand M. Iyer, Roberta Vertemara, Mirjana Carli, Alessandra Agresti, Antonella Antonelli, Marco E. Bianchi, Eleonora Aronica, Teresa Ravizza, Annamaria Vezzani
Format: Article
Language:English
Published: Elsevier 2013-10-01
Series:Neurobiology of Disease
Subjects:
Alarmin
Cell loss
Damage associated molecular pattern
DAMP
Glia
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113000946

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http://www.sciencedirect.com/science/article/pii/S0969996113000946

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