Empagliflozin alleviates renal inflammation and oxidative stress in streptozotocin-induced diabetic rats partly by repressing HMGB1-TLR4 receptor axis

Empagliflozin alleviates renal inflammation and oxidative stress in streptozotocin-induced diabetic rats partly by repressing HMGB1-TLR4 receptor axis

Objective(s): Empagliflozin, a sodium-glucose cotransporter-2 (SGLT-2) inhibitor, possesses verified anti-inflammatory and anti-oxidative stress effects against diabetic nephropathy. The present investigation aims to examine empagliflozin effects on the renal levels of high mobility group box-1 (HMG...

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Bibliographic Details
Main Authors: Zahra Ashrafi Jigheh, Amir Ghorbani Haghjo, Hassan Argani, Leila Roshangar, Nadereh Rashtchizadeh, Davoud Sanajou, Saeed Nazari Soltan Ahmad, Jalil Rashedi, Siavoush Dastmalchi, Mehran Mesgari Abbasi
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2019-04-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Diabetic nephropathy
Empagliflozin
HMGB1
Inflammation
TLR-4
Online Access:http://ijbms.mums.ac.ir/article_12191_01bb220561aa9b474b650c13af13af02.pdf

Internet

http://ijbms.mums.ac.ir/article_12191_01bb220561aa9b474b650c13af13af02.pdf

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