Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo

Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo

The apicomplexan parasite Neospora caninum is an important causative agent of congenital neosporosis, resulting in abortion, birth of weak offspring and neuromuscular disorders in cattle, sheep, and many other species. Among several compound classes that are currently being developed, two have been...

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Bibliographic Details
Main Authors: Nicoleta Anghel, Dennis Imhof, Pablo Winzer, Vreni Balmer, Jessica Ramseier, Kai Haenggeli, Ryan Choi, Matthew A. Hulverson, Grant R. Whitman, Samuel L.M. Arnold, Kayode K. Ojo, Wesley C. Van Voorhis, J. Stone Doggett, Luis M. Ortega-Mora, Andrew Hemphill
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Endochin-like quinolones
Bumped kinase inhibitors
Cytochrome bc1
Calcium-dependent protein kinase inhibitor
Neosporosis
Tachyzoites
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320721000439

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http://www.sciencedirect.com/science/article/pii/S2211320721000439

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