COX-2-dependent and -independent biosynthesis of dihydroxy-arachidonic acids in activated human leukocytes

COX-2-dependent and -independent biosynthesis of dihydroxy-arachidonic acids in activated human leukocytes

Biosynthesis of 5,15-dihydroxyeicosatetraenoic acid (5,15-diHETE) in leukocytes involves consecutive oxygenation of arachidonic acid by 5-lipoxygenase (LOX) and 15-LOX in either order. Here, we analyzed the contribution of cyclooxygenase (COX)-2 to the biosynthesis of 5,15-diHETE and 5,11-diHETE in...

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Bibliographic Details
Main Authors: Noemi Tejera, William E. Boeglin, Takashi Suzuki, Claus Schneider
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Journal of Lipid Research
Subjects:
5-lipoxygenase
leukotriene
prostaglandin
15-lipoxygenase
aspirin
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520408028

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http://www.sciencedirect.com/science/article/pii/S0022227520408028

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