Fragile X Mental Retardation Protein positively regulates PKA anchor Rugose and PKA activity to control actin assembly in learning/memory circuitry

Fragile X Mental Retardation Protein positively regulates PKA anchor Rugose and PKA activity to control actin assembly in learning/memory circuitry

Recent work shows Fragile X Mental Retardation Protein (FMRP) drives the translation of very large proteins (>2000 aa) mediating neurodevelopment. Loss of function results in Fragile X syndrome (FXS), the leading heritable cause of intellectual disability (ID) and autism spectrum disorder (ASD)....

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Bibliographic Details
Main Authors: James C. Sears, Woong Jae Choi, Kendal Broadie
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Neurobiology of Disease
Subjects:
Fragile X syndrome (FXS)
Neurobeachin (NBEA)
A-Kinase Anchor Protein (AKAP)
Protein Kinase A (PKA)
Mushroom Body
Drosophila
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611930035X

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http://www.sciencedirect.com/science/article/pii/S096999611930035X

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