Direct Functional Protein Delivery with a Peptide into Neonatal and Adult Mammalian Inner Ear In Vivo

Direct Functional Protein Delivery with a Peptide into Neonatal and Adult Mammalian Inner Ear In Vivo

The aim of this study was to study an antimicrobial peptide (AMP), aurein 1.2, which substantially increased protein delivery directly into multiple mammalian inner-ear cell types in vivo. Different concentrations of aurein 1.2 with superpositively charged GFP (+36 GFP) protein fused with Cre recomb...

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Bibliographic Details
Main Authors: Kun Zhang, Xiaoting Cheng, Liping Zhao, Mingqian Huang, Yong Tao, Hongbo Zhang, Jessica M. Rosenholm, Min Zhuang, Zheng-Yi Chen, Bing Chen, Yilai Shu
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
inner ear
antibacterial peptides
aurein 1.2
supercharged GFP
targeted delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120301479

Internet

http://www.sciencedirect.com/science/article/pii/S2329050120301479

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