Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4+ T Cells in Type 1 Diabetes

Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4+ T Cells in Type 1 Diabetes

In Type 1 Diabetes (T1D), CD4+ T cells initiate autoimmune attack of pancreatic islet β cells. Importantly, bioenergetic programs dictate T cell function, with specific pathways required for progression through the T cell lifecycle. During activation, CD4+ T cells undergo metabolic reprogramming to...

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Bibliographic Details
Main Authors: Christina P. Martins, Lee A. New, Erin C. O’Connor, Dana M. Previte, Kasey R. Cargill, Isabelle L. Tse, Sunder Sims- Lucas, Jon D. Piganelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
glycolysis
type 1 diabetes
immunometabolism
T cell exhaustion
autoimmunity
PD-1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.669456/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.669456/full

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