Molecular and epigenetic profiles of BRCA1-like hormone-receptor-positive breast tumors identified with development and application of a copy-number-based classifier

Molecular and epigenetic profiles of BRCA1-like hormone-receptor-positive breast tumors identified with development and application of a copy-number-based classifier

Abstract Background BRCA1-mutated cancers exhibit deficient homologous recombination (HR) DNA repair, resulting in extensive copy number alterations and genome instability. HR deficiency can also arise in tumors without a BRCA1 mutation. Compared with other breast tumors, HR-deficient, BRCA1-like tu...

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Bibliographic Details
Main Authors: Youdinghuan Chen, Yue Wang, Lucas A. Salas, Todd W. Miller, Kenneth Mark, Jonathan D. Marotti, Arminja N. Kettenbach, Chao Cheng, Brock C. Christensen
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Breast Cancer Research
Subjects:
BRCA1
BRCAness
Breast cancer
DNA methylation
Homologous recombination
Precision medicine
Online Access:http://link.springer.com/article/10.1186/s13058-018-1090-z

Internet

http://link.springer.com/article/10.1186/s13058-018-1090-z

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